Ralf Rangnick's Red Devils are at St. James' Park on Monday night for a sold-out clash under the lights (kick-off 8pm GMT).
And Newcastle United know that three points are a must if they are to climb out of the relegation places as they head into 2022.
Eddie Howe's men have been on the wrong end of some controversial refereeing decisions in recent weeks, and will be without Isaac Hayden for Monday's game after the midfielder picked up his fifth booking of the season against Manchester City at the weekend.
But Javier Manquillo was back in training after he missed Sunday's match through illness, while Paul Dummett has also started to step up his recovery from injury. Serena Taylor brought nufc.co.uk this gallery from the Magpies' bitterly cold Benton base.
