The Red Devils are rightly favourites this weekend as they have won 15 away matches since the start of last season - four more than any other side.
Newcastle did triumph over them 3-0 back in January, however, but the Magpies' longer term record is less impressive, with 13 losses and five draws from the last 18 meetings between the sides.
A draw could be a good shout for Newcastle though as they have drawn half of their last 12 home games against top six sides. In addition, four of the last eight fixtures between these two teams have been level at the break.
Manchester United have been prolific so far this season, but Newcastle could make this a tight match. Seven of Newcastle's last nine home matches have had fewer than three goals, with five clean sheets. Under 2.5 match goals looks cracking value at 23/20, with correct score 1-1 worth a look at 7/1.
Demba Ba and Papiss Cisse are both 7/1 to score first for Newcastle, with Robin van Persie the favourite to net first at 4/1.
For all the best odds from the only bookie that wants you to win, visit Bet Butler.
(Bet Butler round up the best betting ideas from the world of football)
// Schalke v Wolfsburg - German Bundesliga: Schalke 04 have won 7/8 home matches against bottom-six teams while Wolfsburg have lost 10/10 away matches against top-six teams. Wolfsburg have had L/L double results in 8/10 away matches against top-six teams. Schalke half-time/full-time @ 5/4
// Ebbsfleet Utd v Kidderminster - Blue Square Premier: There have been +2.5 goals in 5/6 Ebbsfleet Utd home matches against bottom-six teams and in 11/20 Kidderminster away matches. Over 2.5 goals @ 8/11
// Barcelona v Real Madrid - Spanish La Liga: The second half as been the highest scoring half in 6 of the last 9 meetings between these sides and in 14/22 Real away matches since the start of last season. Second half to be the highest scoring half @ 21/20
(Odds correct as of Thursday, 4th October at 3pm)